Actin dynamics and cell fate acquisition in C. elegans.
Type | Post-doc |
Proposé le 28/05/2020, valable jusqu'au 30/09/2020 | |
Lieu | IGBMC Strasbourg |
Domaine | actin dynamics in C elegans embryo |
Contact | Anne-Cécile Reymann |
Descriptif | CRISPR targeted mutagenesis of C. elegans actin: novel insights into the understanding of human non-muscle actinopathies. Human mutations in the cytoplasmic actin genes ACTB and ACTG1 (beta- and gamma-cytoskeletal actin isoforms) cause a broad spectrum of rare disorders named Non-Muscle Actinopathies (NMAs). The objective of this project, is first to reproduce these specific human single point substitutions in the model organism C. elegans using CRISPR/Cas9 mediated genome engineering, second to use these mutants to assess in a simple model system, the developmental defects as well as the perturbation of actin organization and actin dynamics induced by these specific actin variants. |