Équipe : Physical mechanisms at cellular and subcellular scales
Responsable : Emmanuèle HELFER
Laboratoire : UMR 7325 Centre Interdisciplinaire de Nanoscience de Marseille (Marseille)
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Descriptif :
We are interested in biomimetic approaches combining microfluidics and microscopy to decipher biological processes, from the subcellular scale to the multicellular scale. At the subcellular scale, we reconstitute in vitro actin-based processes with minimal systems (synthetic membranes, purified proteins) in order to control physical and biochemical parameters. From mesoscopic observations (with optical microscopy techniques) we derive molecular interplays and self-assembly dynamics (protein-protein, protein-membrane interactions). At the cellular/multicellular scale, we investigate the dynamics of cells under mechanical constraint, in healthy and pathological conditions. Keywords: Biological physics, in vitro approach, cell mechanics and dynamics, pathologies, actin-based processes, membrane physics
We are interested in biomimetic approaches combining microfluidics and microscopy to decipher biological processes, from the subcellular scale to the multicellular scale. At the subcellular scale, we reconstitute in vitro actin-based processes with minimal systems (synthetic membranes, purified proteins) in order to control physical and biochemical parameters. From mesoscopic observations (with optical microscopy techniques) we derive molecular interplays and self-assembly dynamics (protein-protein, protein-membrane interactions). At the cellular/multicellular scale, we investigate the dynamics of cells under mechanical constraint, in healthy and pathological conditions. Keywords: Biological physics, in vitro approach, cell mechanics and dynamics, pathologies, actin-based processes, membrane physics
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