Équipe : Biomimétisme du mouvement cellulaire
Responsable : Cécile Sykes et Julie Plastino
Laboratoire : UMR 168 Physico-Chimie Curie (Curie)
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Descriptif :
We study how cells change shape and move, with implications for understanding cancer invasion and metastasis. Our approach is based on the study of in vitro biomimetic systems and in vivo cellular and animal models to dissect the physical and biochemical mechanisms governing cell shape change and movement. We observe specifically actin, a dynamic biopolymer that constitutes part of the cell architecture and mechanics. We use techniques such as optical microscopy, micropipette aspiration, optical tweezers, microrheology, microfluidics and apply these techniques to cells, nematode worms and embryos, chicken embryos and mouse oocytes
We study how cells change shape and move, with implications for understanding cancer invasion and metastasis. Our approach is based on the study of in vitro biomimetic systems and in vivo cellular and animal models to dissect the physical and biochemical mechanisms governing cell shape change and movement. We observe specifically actin, a dynamic biopolymer that constitutes part of the cell architecture and mechanics. We use techniques such as optical microscopy, micropipette aspiration, optical tweezers, microrheology, microfluidics and apply these techniques to cells, nematode worms and embryos, chicken embryos and mouse oocytes
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