Équipe : Signalisation et infections bactériennes
Responsable : Cécile Arrieumerlou
Laboratoire : UMR 8104 Institut Cochin (Hôpital Cochin)
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Descriptif :
Bacterial infections represent a rising threat on human health. They result from complex molecular interactions between a large number of microbial components and host factors, and therefore, need to be addressed on a global scale. Using the enteroinvasive bacterium Shigella flexneri as main model of infection, we combine systems biology methods and mechanistic approaches to characterize the host molecular pathways involved in several key aspects of bacterial infections including invasion of epithelial cells, host cell survival and inflammation.
Bacterial infections represent a rising threat on human health. They result from complex molecular interactions between a large number of microbial components and host factors, and therefore, need to be addressed on a global scale. Using the enteroinvasive bacterium Shigella flexneri as main model of infection, we combine systems biology methods and mechanistic approaches to characterize the host molecular pathways involved in several key aspects of bacterial infections including invasion of epithelial cells, host cell survival and inflammation.
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