Équipe : Active Cell Matter
Responsable : Cécile Sykes et Julie Plastino
Laboratoire : UMR 8023 Laboratoire de Physique de l'ENS (ENS Paris)
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Descriptif :
We combine soft matter biophysics, theoretical analysis and modeling, and in vivo and in vitro experiments to unveil the physical laws that control the transformations of living matter. In particular, we are interested in active nuclear dynamics in confined cellular environments, relevant for understanding diverse biological processes, from tumor metastasis to cell differentiation. Our approach is based in part on our previous work, involving the design of controlled biomimetic systems that allowed “coarse-grained” soft-matter modeling of forces generated by the dynamic assembly of the cytoskeleton, in particular actin. Indeed, the dynamic cytoskeleton is known to play a role in active nuclear dynamics.
We combine soft matter biophysics, theoretical analysis and modeling, and in vivo and in vitro experiments to unveil the physical laws that control the transformations of living matter. In particular, we are interested in active nuclear dynamics in confined cellular environments, relevant for understanding diverse biological processes, from tumor metastasis to cell differentiation. Our approach is based in part on our previous work, involving the design of controlled biomimetic systems that allowed “coarse-grained” soft-matter modeling of forces generated by the dynamic assembly of the cytoskeleton, in particular actin. Indeed, the dynamic cytoskeleton is known to play a role in active nuclear dynamics.
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