Équipe : Zebrafish Neurogenetics
Responsable : Laure Bally-Cuif
Laboratoire : UMR 3738 Bases génétiques, moléculaires et cellulaires du développement (Pasteur Paris)
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Descriptif :
We are interested in the biology of adult neural stem cells (NSCs) in vivo, and in particular in the emergent properties resulting from the arrangement of NSCs in pools within the adult vertebrate brain. More specifically, we are studying how the spatio-temporal organization of these pools interacts with the state (quiescence and stemness) of individual NSCs within the pool, to maintain a dynamic homeostasis of the system over large time scales (several months). Technically, we rely on live imaging of adult NSCs in their in vivo niche, quatitative biology approaches including (in collaboration) mathematical and biophysics modeling, and functional genetics. Our model system is the adult telencephalon of the zebrafish.
We are interested in the biology of adult neural stem cells (NSCs) in vivo, and in particular in the emergent properties resulting from the arrangement of NSCs in pools within the adult vertebrate brain. More specifically, we are studying how the spatio-temporal organization of these pools interacts with the state (quiescence and stemness) of individual NSCs within the pool, to maintain a dynamic homeostasis of the system over large time scales (several months). Technically, we rely on live imaging of adult NSCs in their in vivo niche, quatitative biology approaches including (in collaboration) mathematical and biophysics modeling, and functional genetics. Our model system is the adult telencephalon of the zebrafish.
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