Équipe : Regulation of microtubule dynamics and functions
Responsable : Carsten Janke
Laboratoire : UMR 3348 Stress génotoxique et cancer (Curie)
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Descriptif :
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell division, shaping, intracellular transport, and motility. Despite their functional heterogeneity, MTs have highly conserved structures made from almost identical molecular building blocks – tubulin proteins. Alternative tubulin isotypes and a variety of posttranslational modifications (PTMs) control the properties and functions of the MT cytoskeleton, a concept known as the ‘tubulin code’. While they have mostly gradual effects at the molecular level, isotypes and PTMs appear essential for maintaining cellular functions of microtubules over greater time and size scales. Yet a comprehensive understanding of the principles of the tubulin code, connecting its functions from the molecular to the cellular and organismal level, is almost entirely lacking. Our team aims at obtaining a novel molecular and mechanistic understanding of how tubulin PTMs and isotypes control long-term cellular functions and homeostasis, using an interdisciplinary approach bridging biochemistry, single-molecule assays, cell biology, and animal physiology.
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell division, shaping, intracellular transport, and motility. Despite their functional heterogeneity, MTs have highly conserved structures made from almost identical molecular building blocks – tubulin proteins. Alternative tubulin isotypes and a variety of posttranslational modifications (PTMs) control the properties and functions of the MT cytoskeleton, a concept known as the ‘tubulin code’. While they have mostly gradual effects at the molecular level, isotypes and PTMs appear essential for maintaining cellular functions of microtubules over greater time and size scales. Yet a comprehensive understanding of the principles of the tubulin code, connecting its functions from the molecular to the cellular and organismal level, is almost entirely lacking. Our team aims at obtaining a novel molecular and mechanistic understanding of how tubulin PTMs and isotypes control long-term cellular functions and homeostasis, using an interdisciplinary approach bridging biochemistry, single-molecule assays, cell biology, and animal physiology.
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