Équipe : Biologie du Système Circadien
Responsable : Franck Delaunay
Laboratoire : UMR 7277 Insitut de Biologie Valrose (Nice)
()
Descriptif :
The mammalian circadian timing system coordinates a variety of molecular, cellular and physiological processes over the 24 h in synchrony with the light/dark cycle. The fundamental mechanism underlying circadian rhythms is a molecular clock present in virtually all body cells. The system is organized hierarchically with a central clock in the hypothalamus that coordinates peripheral clocks through internal synchronizers. Misalignment or disruption of the human circadian timing system has been linked to pathologies including metabolic disorders, sleep phase syndromes and cancer. Although we currently have a comprehensive view of how core clock genes work and interact together to generate oscillations, we still do not fully understand how they crosstalk with other essential cellular mechanisms. In that context, we study how mammalian peripheral circadian clocks interact with the cell cycle and metabolic processes and determine the relevance of these interactions in health and disease.
The mammalian circadian timing system coordinates a variety of molecular, cellular and physiological processes over the 24 h in synchrony with the light/dark cycle. The fundamental mechanism underlying circadian rhythms is a molecular clock present in virtually all body cells. The system is organized hierarchically with a central clock in the hypothalamus that coordinates peripheral clocks through internal synchronizers. Misalignment or disruption of the human circadian timing system has been linked to pathologies including metabolic disorders, sleep phase syndromes and cancer. Although we currently have a comprehensive view of how core clock genes work and interact together to generate oscillations, we still do not fully understand how they crosstalk with other essential cellular mechanisms. In that context, we study how mammalian peripheral circadian clocks interact with the cell cycle and metabolic processes and determine the relevance of these interactions in health and disease.
Thèmes :
Chercheurs :
Modifier les
données de l'équipe (réservé aux membres de l'équipe)