Équipe : Quantitative immuno-hematology
Responsable : Leila Perié
Laboratoire : UMR 168 Physico-Chimie Curie (Curie)
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Descriptif :
The immune system is composed of diverse, functionally distinct cell types that each contributes uniquely to immune responses. During adulthood, these diverse cell types originate from hematopoietic stem cells though a process called hematopoiesis. Our research interest lies in understanding quantitatively how this diversity is produced and maintained during homeostasis and infection. To tangle this question, we combine experimental and computational approaches of single cell analysis. In particular, we use a lineage tracing method called cellular barcoding that tracks the descendants of individual cells. In addition, our research aims at developing new lineage tracing methodologies to study hematopoiesis not only in mice but also in humans.
The immune system is composed of diverse, functionally distinct cell types that each contributes uniquely to immune responses. During adulthood, these diverse cell types originate from hematopoietic stem cells though a process called hematopoiesis. Our research interest lies in understanding quantitatively how this diversity is produced and maintained during homeostasis and infection. To tangle this question, we combine experimental and computational approaches of single cell analysis. In particular, we use a lineage tracing method called cellular barcoding that tracks the descendants of individual cells. In addition, our research aims at developing new lineage tracing methodologies to study hematopoiesis not only in mice but also in humans.
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