Séminaire externe : Raouf El Cheikh
Séance du mercredi 01 avril 2015, 11:00 - 12:30,
Salle du conseil de l'UFR de Physique (Bât. P5 bis, 252)
Modeling circadian clock-cell cycle interaction effects on cell population growth rates
Raouf El Cheikh
INRIA Rhône-Alpes, antenne de Lyon
The circadian clock and the cell cycle are two tightly coupled oscillators. Recent analytical studies have shown counter-intuitive effects of circadian gating of the cell cycle on growth rates of proliferating cells which cannot be explained by a molecular model or a population model alone. In this talk, we present a combined molecular-population model that studies how coupling the circadian clock to the cell cycle, through the protein WEE1, affects a pro- liferating cell population. We show that the cell cycle can entrain to the circadian clock with different rational period ratios and characterizes multiple domains of entrainment. We show that coupling increases the growth rate for autonomous periods of the cell cycle around 24 h and above 48 h. We examine the effect of mutation of circadian genes on the growth rate of cells and show that disruption of the circadian clock can lead to abnormal proliferation. Combining a molecular model to a population model offers new insight on the in uence of the circadian clock on the growth of a cell population. This can help chronotherapy which takes benefits of physiological rhythms to improve anti-cancer ecacy and tolerance to drugs by administering treatments at a specific time of the day.