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Type
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Thèse |
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Proposé le 19/02/2018, valable
jusqu'au 1/11/2018 |
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Lieu
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IGBMC, Strasbourg |
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Domaine
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Cell Biology, Biochemistry |
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Contact
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Anne-Cécile Reymann |
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Descriptif
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Cell architectures equilibrate and remodel perpetually. The cellular cortex is an active material that allows cells to maintain their shape, produce or sense forces. It is a submicron network under the cell membrane consisting mostly of actin filaments and myosin molecular motors. This actin cortex is key in maintaining such dynamical equilibrium by constant assembly-disassembly processes using a wide palette of molecular building blocks.
The specific aim of this PhD will be to fully understand the process of cortical actin assembly and answer the how/when/where questions related to it. We will start by characterizing the molecular orchestration of actin and actin binding molecules during the cortical assembly process in the C. elegans early embryo.
3 year PhD at the interface of cell biology/live imaging /quantitative biology/biophysics.
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