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Characterizing Cell Adhesion by Using Micropipette Aspiration

B. Hogan, A. Babataheri, Y. Hwang, A. I. Barakat, and J. Husson

Biophysical Journal 109, 209-219 (2015) [Accès à la revue]

We have developed a technique to quantify cell-substrate adhesion force using micropipette aspiration. We position a micropipette perpendicular to the surface of an adherent cell and we apply a constant-rate aspiration pressure. We find that the detachment force scales with the cell adhesion area; this defines a critical stress, which depends on the applied aspiration rate.

Thème : Mécanique cellulaire

Equipe : Génie Cellulaire et Cardiovasculaire (LadHyX)